[The luteotropic and luteolytic properties of synthetic analogs of 11-deoxy-PGE1].

The luteotropic and luteolytic properties of synthetic analogues of 11-desoxy-PGE1 were studied. Compounds Nos. 1 and 2 depending on the dose exerted the opposite effect: in low doses--luteotropic, in high doses--luteolytic. Compounds Nos. 3, 4 and 5 in the whole range of doses exhibited only luteolytic properties. The ranges of doses of prostaglandin exerting the luteotropic effect depend on the structural modifications of prostaglandin molecule. The luteolytic effect of synthetic analogue No. 5 was suggested to be determined by its influence on the hypophysis through the change of contents of cyclic nucleotides and gonadotropic hormones. It was demonstrated that the luteolytic effect of compound No. 5 is realized through the central nervous system, in particular, through the hypophysis.