Beliaeva M L
Farmakol Toksikol. 1990 Nov-Dec;53(6):46-8.
The summary levels of diazepam and its metabolites in the mouse serum, brain and liver tissues were determined by the radioreceptor assay after single intraperitoneal administration of seduxen in a dose of 4 mg/kg. The results showed synchronism of changes of the concentrations in the brain and liver and in the serum. The correlation coefficients between the brain or liver concentrations and the serum one were 0.82 and 0.91, respectively. The second peak of the tissue concentrations of diazepam active forms and the local minimum at this time in the serum were observed 2.5 hours after the drug administration. The results obtained may be considered as the experimental basis of using the blood diazepam active form concentrations measured by RRA for the therapeutic control of diazepam application in the clinic.
单次腹腔注射4mg/kg速可眠后，采用放射受体分析法测定小鼠血清、脑和肝组织中地西泮及其代谢物的总含量。结果表明，脑、肝和血清中浓度变化具有同步性。脑浓度与血清浓度、肝浓度与血清浓度之间的相关系数分别为0.82和0.91。给药后2.5小时观察到地西泮活性形式的组织浓度出现第二个峰值，此时血清中出现局部最小值。所获得的结果可被视为将放射受体分析法测定的血液中地西泮活性形式浓度用于临床地西泮应用治疗控制的实验依据。
