Chernov Iu N, Batishcheva G A, Vasin M V
Farmakol Toksikol. 1990 Nov-Dec;53(6):64-71.
The biological role and pharmacological effects of prostanoids and leukotrienes are considered, the relationship with the actions of more than 80 drugs changing in this or that way their level in the organism is analysed. New substances and drugs--synthetic analogues of prostanoids and leukotrienes, blockers of their synthesis as well as activators and inhibitors of their metabolism are presented. The perspectives of their clinical use are discussed.
本文探讨了前列腺素和白三烯的生物学作用及药理效应,分析了80多种药物的作用与机体中它们水平变化之间的关系。文中介绍了新的物质和药物——前列腺素和白三烯的合成类似物、其合成阻滞剂以及代谢激活剂和抑制剂,并讨论了它们的临床应用前景。