血液透析和腹膜透析对慢性肾衰竭患者氧化还原状态的影响：一项对比研究。
Effect of hemodialysis and peritoneal dialysis on redox status in chronic renal failure patients: a comparative study.
机构信息
Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences, Université d'Oran 31100, Algérie.
出版信息
Lipids Health Dis. 2010 Sep 3;9:93. doi: 10.1186/1476-511X-9-93.
OBJECTIVE
To investigate the effects of hemodialysis (HD) and periotoneal dialysis (PD) on oxidative stress in chronic renal failure patients (CRF).
METHODS
20 HD patients (M/F: 8/12, 36 ± 12 years) and 20 PD patients (M/F: 10/10, 40 ± 8 years) were compared with 20 end stage renal failure patients (CRF) (M/F: 4/16, 61 ± 13 years).
RESULTS
Thiobarbituric acid reactive substances (TBARS) values were elevated in HD and decreased in PD compared to CRF (P < 0.05). TBARS-VLDL and TBARS-HDL2 were decreased in HD and PD, compared to CRF (p < 0.05). TBARS-LDL were higher in HD compared to CRF (p < 0.05). No significant difference in TBARS-HDL3 values between the three groups. Carbonyls were increased in HD (p < 0.05) and PD (p < 0.01) compared to CRF. Plasma superoxide dismutase activity (SOD) was decreased in HD compared to CRF and PD (P < 0.05). Glutathion peroxidase activity (GSH-Px) was decreased in HD and PD (P < 0.005), compared to CRF. Decrease in catalase activity was noted only in PD compared to CRF (P < 0.05). An increase in nitric oxide was noted in HD compared to CRF (p < 0.05). Albumin concentrations were higher in HD and PD compared to CRF (P < 0.001). Whereas uric acid concentrations were decreased in HD (P < 0.001) compared to CRF and PD. Bilirubin values were similar in all groups. Increased values of iron were noted in HD and PD, compared to PD (p < 0.001).
CONCLUSION
HD and PD aggravate oxidative stress generated by uremia. HD accentuates lipid and protein peroxidation, while PD aggravates protein oxidation. However, the activity of antioxidant enzymes was altered by both dialysis treatments.
目的
探讨血液透析（HD）和腹膜透析（PD）对慢性肾衰竭患者（CRF）氧化应激的影响。
方法
将 20 例 HD 患者（男/女：8/12，36±12 岁）和 20 例 PD 患者（男/女：10/10，40±8 岁）与 20 例终末期肾衰竭患者（CRF）（男/女：4/16，61±13 岁）进行比较。
结果
与 CRF 相比，HD 患者的硫代巴比妥酸反应物质（TBARS）值升高，PD 患者的 TBARS 值降低（P<0.05）。HD 和 PD 患者的 TBARS-VLDL 和 TBARS-HDL2 降低，与 CRF 相比（p<0.05）。与 CRF 相比，HD 患者的 TBARS-LDL 更高（p<0.05）。三组间 TBARS-HDL3 值无显著差异。与 CRF 相比，HD（p<0.05）和 PD（p<0.01）患者的羰基含量增加。与 CRF 和 PD 相比，HD 患者的血浆超氧化物歧化酶活性（SOD）降低（P<0.05）。HD 和 PD 患者的谷胱甘肽过氧化物酶活性（GSH-Px）降低（P<0.005），与 CRF 相比。仅在 PD 中观察到过氧化氢酶活性降低，与 CRF 相比（P<0.05）。与 CRF 相比，HD 中一氧化氮增加（p<0.05）。与 CRF 相比，HD 和 PD 中的白蛋白浓度更高（P<0.001）。而 HD 中的尿酸浓度降低（P<0.001），与 PD 相比。各组胆红素值相似。与 PD 相比，HD 和 PD 中的铁含量增加（p<0.001）。
结论
HD 和 PD 加重了尿毒症引起的氧化应激。HD 加重脂质和蛋白质过氧化，而 PD 加重蛋白质氧化。然而，两种透析治疗都改变了抗氧化酶的活性。
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