可卡因选择性增加成年小鼠海马体的增殖。
Cocaine selectively increases proliferation in the adult murine hippocampus.
机构信息
Department of Psychology, North Georgia College & State University, 82 College Circle, Dunlap Hall, Room 202B, Dahlonega, GA 30597, USA.
出版信息
Neurosci Lett. 2010 Nov 19;485(2):112-6. doi: 10.1016/j.neulet.2010.08.080. Epub 2010 Sep 15.
Abstract
Cocaine abuse continues to be a significant problem in the USA and elsewhere. Cocaine is an indirect agonist for dopamine, norepinephrine and serotonin with numerous potential downstream effects, including processes and signals associated with adult neurogenesis. Since drug addiction is associated with brain plasticity, we hypothesized that cocaine exposure would alter cellular proliferation in two adult neurogenic regions (the subventricular and subgranular zones). We used bromodeoxyuridine (BrdU) to track newly generated cells in the brains of adult mice after chronic cocaine or saline exposures. No differences were found in the number or migration patterns of BrdU-labeled cells in the forebrain neurogenic areas. However, cocaine produced a significant increase in the number of hippocampal BrdU-labeled cells.
摘要
可卡因滥用在美国和其他地方仍然是一个严重的问题。可卡因是多巴胺、去甲肾上腺素和血清素的间接激动剂，具有许多潜在的下游效应，包括与成人神经发生相关的过程和信号。由于药物成瘾与大脑可塑性有关，我们假设可卡因暴露会改变两个成年神经发生区域（室下区和颗粒下区）的细胞增殖。我们使用溴脱氧尿苷（BrdU）来跟踪成年小鼠在慢性可卡因或生理盐水暴露后大脑中新生成的细胞。在前脑神经发生区域，BrdU 标记细胞的数量或迁移模式没有差异。然而，可卡因使海马 BrdU 标记细胞的数量显著增加。
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