Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Psychiatry Res. 2010 Oct 30;184(1):1-9. doi: 10.1016/j.pscychresns.2010.06.003.
The present study aimed to investigate the presence of corpus callosum (CC) volume deficits in a population-based recent-onset psychosis (ROP) sample, and whether CC volume relates to interhemispheric communication deficits. For this purpose, we used voxel-based morphometry comparisons of magnetic resonance imaging data between ROP (n =122) and healthy control (n = 94) subjects. Subgroups (38 ROP and 39 controls) were investigated for correlations between CC volumes and performance on the Crossed Finger Localization Test (CFLT). Significant CC volume reductions in ROP subjects versus controls emerged after excluding substance misuse and non-right-handedness. CC reductions retained significance in the schizophrenia subgroup but not in affective psychoses subjects. There were significant positive correlations between CC volumes and CFLT scores in ROP subjects, specifically in subtasks involving interhemispheric communication. From these results, we can conclude that CC volume reductions are present in association with ROP. The relationship between such deficits and CFLT performance suggests that interhemispheric communication impairments are directly linked to CC abnormalities in ROP.
本研究旨在探讨基于人群的首发精神病（ROP）样本中胼胝体（CC）体积缺陷的存在情况，以及 CC 体积是否与半球间通讯缺陷有关。为此，我们使用磁共振成像数据的基于体素形态计量学比较，比较了 ROP（n=122）和健康对照组（n=94）受试者。对 38 名 ROP 和 39 名对照组受试者进行了 CC 体积与交叉手指定位测试（CFLT）表现之间的相关性研究。在排除物质滥用和非右利手后，ROP 受试者与对照组相比出现了显著的 CC 体积减少。CC 减少在精神分裂症亚组中仍有意义，但在情感性精神病患者中则没有。ROP 受试者的 CC 体积与 CFLT 评分之间存在显著的正相关，特别是在涉及半球间通讯的子任务中。从这些结果可以得出结论，CC 体积减少与 ROP 有关。这些缺陷与 CFLT 表现之间的关系表明，半球间通讯损伤与 ROP 中的 CC 异常直接相关。
