Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada.
Vet Pathol. 2011 Nov;48(6):1212-5. doi: 10.1177/0300985810381246. Epub 2010 Sep 3.
Parenteral selenium (Se) and vitamin E (Vit E) were administered to all newborn kids at a Boer goat farm where there was previous high neonatal mortality assumed to be due to nutritional myopathy. All treated kids were affected by severe respiratory distress and died within 8 hours of Se/Vit E administration. Gross lesions included severe pulmonary edema, hydrothorax, and hydropericardium. The primary histopathologic finding was severe, acute, and monophasic myocardial contraction band necrosis. The diagnosis was accidental acute selenosis based on trace mineral analysis of the liver. This case highlights an important differential diagnosis in cases of acute myocardial contraction band necrosis and sudden death in goats and emphasizes the need for caution when administering parenteral Se/Vit E preparations.
波尔山羊养殖场的所有新生羊羔都接受了静脉注射硒(Se)和维生素 E(Vit E),此前该养殖场的新生羊羔死亡率很高,据认为是由于营养性肌病所致。所有接受治疗的羊羔都出现严重的呼吸窘迫,并在给予 Se/Vit E 后 8 小时内死亡。大体病变包括严重肺水肿、胸腔积液和心包积液。主要组织病理学发现是严重、急性和单相的心肌收缩带坏死。根据肝脏微量元素分析,诊断为意外急性硒中毒。本病例强调了在急性心肌收缩带坏死和山羊猝死的病例中需要进行的重要鉴别诊断,并强调了在给予静脉注射 Se/Vit E 制剂时需要谨慎。