Bazard M C, Becker A, Berrod J P, Raspiller A
Service d'ophtalmologie, Hôpital central, Nancy.
J Fr Ophtalmol. 1990;13(8-9):434-40.
The goal of this study was to establish the incidence of chorioretinitis in 100 infants whose mothers presented a seroconversion during the pregnancy. It is a retrospective study over 6.5 years. There were 17 cases of latent congenital toxoplasmosis (56.7%) and 13 cases of clinical congenital toxoplasmosis (43.3%). Three infants presented with chorioretinitis: one at birth in a context of general stroke, the two others at 2 and 17 months after birth, despite treatment. The risk of retinochorioditis was the same in the case of latent or clinical congenital toxoplasmosis. The fall in the antibody titre was not a good criterion of cure; the percentage of lymphocytes in the cerebrospinal fluid could constitute a better criterion. This study confirmed the efficacy of systemic treatment of congenital toxoplasmosis.
本研究的目的是确定100名母亲在孕期出现血清转化的婴儿中脉络膜视网膜炎的发病率。这是一项为期6.5年的回顾性研究。有17例潜伏性先天性弓形虫病（56.7%）和13例临床先天性弓形虫病（43.3%）。三名婴儿出现脉络膜视网膜炎：一名在出生时伴有全身性中风，另外两名在出生后2个月和17个月出现，尽管接受了治疗。潜伏性或临床先天性弓形虫病患者发生视网膜脉络膜炎的风险相同。抗体滴度下降不是治愈的良好标准；脑脊液中淋巴细胞的百分比可能是更好的标准。本研究证实了先天性弓形虫病全身治疗的有效性。
