Okutucu Sercan, Tokgözoğlu Lale
Hacettepe Universitesi Tip Fakültesi, Kardiyoloji Anabilim Dali, Ankara, Türkiye.
Anadolu Kardiyol Derg. 2010 Sep;10 Suppl 2:19-26. doi: 10.5152/akd.2010.126.
Pulmonary arterial hypertension (PAH) is a clinical syndrome that is often diagnosed late and is associated with a progressive clinical deterioration and death. However, over the past ten years there has been a dramatic increase in the number of effective therapies. Identification of dysfunctional pathways in the pulmonary circulation provided novel therapeutic targets with the goal of reducing pulmonary vascular resistance and death from right ventricular failure. Treatment strategies are determined according to current guidelines. Pulmonary artery vasoreactivity, functional class and response to treatment are important concepts for initiation of medical therapy. With the availability of medications that target different pathologic processes, combination therapy has become a frequently used therapeutic option in PAH. In this paper, we aimed to review the therapeutic algorithms in pulmonary hypertension based on current guidelines.
肺动脉高压（PAH）是一种临床综合征，常常诊断较晚，且与临床病情进行性恶化及死亡相关。然而，在过去十年中，有效治疗方法的数量有了显著增加。对肺循环中功能失调通路的识别提供了新的治疗靶点，目标是降低肺血管阻力并减少因右心室衰竭导致的死亡。治疗策略根据现行指南确定。肺血管反应性、功能分级及对治疗的反应是启动药物治疗的重要概念。随着针对不同病理过程的药物的出现，联合治疗已成为PAH中常用的治疗选择。在本文中，我们旨在根据现行指南综述肺动脉高压的治疗算法。
