[两种离线方法或NIOXmino测量成年日本哮喘患者呼出一氧化氮分数值的差异]

[Differences in fraction of exhaled nitric oxide values measured by two offline methods or NIOXmino in adult Japanese asthmatics].

作者信息

Tsuburai Takahiro, Tsurikisawa Naomi, Higashi Noritaka, Tatsuno Sayaka, Fukutomi Yuma, Tanimoto Hidenori, Sekiya Kiyoshi, Oshikata Chiyako, Otomo Mamoru, Maeda Yuji, Taniguchi Masami, Ikehara Kunihiko, Akiyama Kazuo

机构信息

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital.

出版信息

Arerugi. 2010 Aug;59(8):956-64.

Abstract

BACKGROUND

The fraction of exhaled nitric oxide (FeNO) is a useful marker of asthma control. The FeNO measurement with two offline methods and NIOXmino may be more affordable, no studies have examined the differences in FeNO values measured with various methods in adult asthmatics.

METHODS

The study population comprised 39 stable asthmatics treated with inhaled steroids at our outpatient clinic. FeNO values were measured by two offline methods (Sievers and CEIS), NIOXmino.

RESULTS

FeNO(NIOXmino) values were significantly correlated with those of FeNO(Sievers) (r=0.935, P< 0.001) and FeNOCEIS (r=0.908, P< 0.001). However, FeNO(NIOXmino) values were low compared with FeNO(Sievers) (FeNO(NIOXmino)=0.848 x FeNO(Sievers)) and FeNO(CEIS) (FeNO(NIOXmino)=0.672 x FeNO(CEIS)).

CONCLUSION

Differences exist in the values of FeNO measured by various methods: conversion equations are needed to compare the FeNO values among these three methods.

摘要

背景

呼出一氧化氮分数（FeNO）是哮喘控制的一个有用指标。采用两种离线方法和NIOXmino测量FeNO可能成本更低，但尚无研究探讨在成年哮喘患者中使用不同方法测量的FeNO值的差异。

方法

研究人群包括在我们门诊接受吸入性类固醇治疗的39例稳定期哮喘患者。采用两种离线方法（Sievers和CEIS）以及NIOXmino测量FeNO值。

结果

FeNO（NIOXmino）值与FeNO（Sievers）值显著相关（r = 0.935，P < 0.001），与FeNO（CEIS）值也显著相关（r = 0.908，P < 0.001）。然而，FeNO（NIOXmino）值低于FeNO（Sievers）值（FeNO（NIOXmino）= 0.848×FeNO（Sievers））以及FeNO（CEIS）值（FeNO（NIOXmino）= 0.672×FeNO（CEIS））。

结论

不同方法测量的FeNO值存在差异：需要转换方程来比较这三种方法测得的FeNO值。