一锅不对称环羰化反应序列用于功能化环戊烷的对映选择性合成。
One-pot asymmetric cyclocarbohydroxylation sequence for the enantioselective synthesis of functionalised cyclopentanes.
机构信息
UMR CNRS 6263 iSm2, Aix-Marseille Université, Centre Saint Jérôme, service 531, 13397 Marseille Cedex 20, France.
出版信息
Chem Commun (Camb). 2010 Oct 14;46(38):7247-9. doi: 10.1039/c0cc01940b. Epub 2010 Aug 27.
PMID:20820517
Abstract
A new method has been developed for the enantioselective synthesis of highly functionalised cyclopentanes bearing up to three stereogenic centres with very high stereoselectivity. This one-pot process combines an enantioselective organocatalytic Michael addition with a highly diastereoselective [3+2]-cycloaddition-fragmentation step.
摘要
一种新的方法已经被开发出来，用于对具有高达三个手性中心的高度官能化的环戊烷进行对映选择性合成，具有非常高的立体选择性。这个一锅法过程结合了对映选择性的有机催化迈克尔加成反应和高度非对映选择性的[3+2]-环加成-重排步骤。
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