Department of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA.
Phys Chem Chem Phys. 2010 Oct 14;12(38):11975-83. doi: 10.1039/c0cp00119h. Epub 2010 Aug 28.
We present a novel microfluidic technique for precise characterization of controlled release of solute from porous latex supraparticles in a laminar flow environment. Dye-infused supraparticles are fabricated via dry self-assembly method using droplet templates dispensed on superhydrophobic substrates. A water-soluble dye is used as a model compound, the release rate of which is measured colorimetrically. The sustained release rates of dye from supraparticles and dye pellets are quantified and compared to common diffusion/dissolution mass transfer models. The results illustrate the potential of microfluidics as a tool in monitoring controlled release process and the role of the uniformly porous supraparticle matrix for the prolonged continuous solute delivery.
我们提出了一种新颖的微流控技术，用于精确描述在层流环境中从多孔乳胶超粒子中控制释放溶质。通过在超疏水基底上分配液滴模板，使用干自组装方法制造染料注入的超粒子。使用水溶性染料作为模型化合物，通过比色法测量其释放速率。定量比较了超粒子和染料微球的染料释放率与常见的扩散/溶解质量传递模型。结果表明，微流控技术作为监测控制释放过程的工具具有潜力，以及均匀多孔超粒子基质在持续连续输送溶质方面的作用。
