State Key Laboratory of Natural and Biomimetic Drugs, Peking University, and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road #38, Beijing 100191, China.
Org Biomol Chem. 2010 Nov 21;8(22):5062-8. doi: 10.1039/c0ob00042f. Epub 2010 Sep 1.
Several iminosugar-based uridine diphosphate galactose (UDP-Gal) mimetics 1-4 including d- and l-epimers were designed and synthesized by concise routes, and these synthetic compounds were evaluated for the inhibition of α-1,3- and β-1,4-galactosyltransferases in vitro. The experimental data demonstrated that l-epimer 2 displayed the strongest inhibitory activity with moderate selectivity against α-1,3-galactosyltransferase.
几种基于亚氨基糖的尿苷二磷酸半乳糖（UDP-Gal）类似物 1-4，包括 d-和 l-差向异构体，通过简洁的路线设计和合成，并对这些合成化合物进行了体外抑制 α-1,3-和 β-1,4-半乳糖基转移酶的活性评价。实验数据表明，l-差向异构体 2 对 α-1,3-半乳糖基转移酶具有最强的抑制活性和中等选择性。
