Nutr Rev. 1990 Dec;48(12):439-40. doi: 10.1111/j.1753-4887.1990.tb02899.x.
Brain histamine levels in rats in various states of water balance were raised by blocking histamine catabolism with metoprine. Acute administration of this drug caused a significant reduction in food intake. This finding suggests a possible role of histamine in the regulation of food intake.
通过用美托普利阻断组胺分解代谢来提高处于各种水平衡状态的大鼠的脑组胺水平。急性给予这种药物会导致食物摄入量显著减少。这一发现表明组胺在食物摄入调节中可能发挥作用。