Makarova O P, Klets E V, Maianskiĭ D N
Patol Fiziol Eksp Ter. 1990 Nov-Dec(6):34-6.
Pneumonia was modelled in experiments on female hybrid mice (CBA X C57Bl)F1 by intratracheal administration of 0.1 ml of 0.4% AgNO3 solution. The functional activity of alveolar macrophages and neutrophils of bronchoalveolar lavage fluid and blood after administration of hydrocortisone (125 mg/kg) was studied in the early stage of pneumonia. The bactericidal and absorptive capacity of neutrophils of the bronchoalveolar lavage fluid and blood diminished considerably under the effect of the hormone. The inhibiting effect of hydrocortisone on the bactericidal activity of alveolar macrophages from the focus of inflammation was more marked than the effect on the cells of the bronchoalveolar lavage fluid from the lungs of intact animals.
通过气管内给予0.1 ml 0.4%硝酸银溶液，在雌性杂交小鼠（CBA×C57Bl）F1的实验中模拟肺炎。在肺炎早期研究了给予氢化可的松（125 mg/kg）后支气管肺泡灌洗液和血液中肺泡巨噬细胞和中性粒细胞的功能活性。在激素的作用下，支气管肺泡灌洗液和血液中中性粒细胞的杀菌和吸收能力显著降低。氢化可的松对炎症灶中肺泡巨噬细胞杀菌活性的抑制作用比对完整动物肺中支气管肺泡灌洗液细胞的作用更明显。
