School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
Urology. 2011 Jan;77(1):237-42. doi: 10.1016/j.urology.2010.06.017. Epub 2010 Sep 6.
To evaluate whether trans-rectal spectral optical tomography of total hemoglobin concentration (HbT) can image longitudinal and lateral developments of a canine transmissible venereal tumor (TVT) in a canine prostate.
A near-infrared (NIR) applicator was integrated with a trans-rectal ultrasound (TRUS) transducer to perform ultrasound (US)-coupled optical tomography of the canine prostate. Spectral detection at 785 and 830 nm enabled quantitation of HbT. Canine TVT cells were injected into the right lobe of a dog's prostate gland. Longitudinal imaging assessment of the post-injection prostate was performed by coupled US/NIR imaging over a 45-day duration.
By day 7, NIR indicated TVT infiltration in the noninjected left prostatic lobe with the gray-scale US indistinct. By day 31, both NIR and gray-scale US revealed more widespread TVT involvement in the left than in the right lobe, as well as an extensive TVT mass in the caudal aspect of the gland, of which the peak HbT increased 3-fold and the mass volume grew exponentially over the 45-day duration. Increased blood supply to the mass was also observed on Doppler US.
TRUS-coupled spectral optical tomography enhances assessment of the laterality and progression of prostate tumor compared with using gray-scale and Doppler TRUS.
评估全血红蛋白浓度（HbT）经直肠光谱光学层析成像是否能对犬传染性会阴肿瘤（TVT）在犬前列腺中的纵向和横向发展进行成像。
将近红外（NIR）施源器与经直肠超声（TRUS）换能器集成，对犬前列腺进行超声（US）耦合光学层析成像。在 785nm 和 830nm 处进行光谱检测，可定量 HbT。将犬 TVT 细胞注射到犬前列腺的右叶。在 45 天的时间内，通过耦合 US/NIR 成像对注射后的前列腺进行纵向成像评估。
第 7 天，NIR 表明 TVT 已渗透到未注射的左前列腺叶，而灰阶 US 显示不明显。第 31 天，NIR 和灰阶 US 均显示左叶比右叶更广泛地受累于 TVT，并且在腺体的尾部有一个广泛的 TVT 肿块，其峰值 HbT 增加了 3 倍，肿块体积在 45 天的时间内呈指数级增长。在多普勒 US 上也观察到肿块的血液供应增加。
与使用灰阶和多普勒 TRUS 相比，TRUS 耦合光谱光学层析成像增强了对前列腺肿瘤侧性和进展的评估。
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