Department of Bioengineering, University of Texas at Arlington, Arlington, Texas 76010, USA.
Am J Pathol. 2013 Feb;182(2):305-11. doi: 10.1016/j.ajpath.2012.07.036. Epub 2012 Dec 5.
Tumor functional and molecular imaging has significantly contributed to cancer preclinical research and clinical applications. Among typical imaging modalities, ultrasonic and optical techniques are two commonly used methods; both share several common features such as cost efficiency, absence of ionizing radiation, relatively inexpensive contrast agents, and comparable maximum-imaging depth. Ultrasonic and optical techniques are also complementary in imaging resolution, molecular sensitivity, and imaging space (vascular and extravascular). The marriage between ultrasonic and optical techniques takes advantages of both techniques. This review introduces tumor functional and molecular imaging using microbubble-based ultrasound and ultrasound-mediated optical imaging techniques.
肿瘤功能和分子成像技术为癌症的临床前研究和临床应用做出了重大贡献。在典型的成像方式中，超声和光学技术是两种常用的方法；它们都具有一些共同的特点，如成本效益高、无电离辐射、相对便宜的造影剂和可比较的最大成像深度。超声和光学技术在成像分辨率、分子灵敏度和成像空间（血管内和血管外）方面也具有互补性。超声和光学技术的结合利用了这两种技术的优势。本综述介绍了基于微泡的超声和超声介导的光学成像技术在肿瘤功能和分子成像中的应用。
