Warwick Z S, Schiffman S S, Anderson J J
Department of Psychology, Duke University, Durham, NC 27706.
Physiol Behav. 1990 Nov;48(5):581-6. doi: 10.1016/0031-9384(90)90195-a.
Weanling rats were fed either a high-fat (30% of calories) or a low-fat (10% of calories) diet for four weeks, after which fat preference was assessed using a choice paradigm. Fat preference was measured during 2-hour intake tests in which three peanut butter/peanut oil mixtures containing 0.50, 0.61, and 0.71 grams fat/gram were offered to each animal. Rats fed the high-fat (HF) diet preferred the highest-fat mixture and consumed more total fat during intake tests than animals fed the low-fat (LF) diet. Intake of NaCl and sucrose solutions was measured during separate intake tests. LF-fed rats drank more NaCl solution than HF-fed rats. Following these tests a subgroup of the LF-fed animals was fed the HF diet, and a subgroup of the HF-fed group was fed the LF diet for a further four weeks. Upon repetition of the intake tests, rats that had been fed the HF diet during the initial four weeks still preferred the highest-fat mixture.
将断乳大鼠分为两组，分别喂食四周高脂肪（占卡路里的30%）或低脂肪（占卡路里的10%）饮食，之后使用选择范式评估脂肪偏好。在2小时的摄入量测试中测量脂肪偏好，测试中向每只动物提供三种含有0.50、0.61和0.71克脂肪/克的花生酱/花生油混合物。喂食高脂肪（HF）饮食的大鼠更喜欢脂肪含量最高的混合物，并且在摄入量测试中比喂食低脂肪（LF）饮食的动物消耗更多的总脂肪。在单独的摄入量测试中测量氯化钠和蔗糖溶液的摄入量。喂食LF饮食的大鼠比喂食HF饮食的大鼠饮用更多的氯化钠溶液。在这些测试之后，将LF喂养组中的一个亚组改为喂食HF饮食，将HF喂养组中的一个亚组改为喂食LF饮食，再持续四周。在重复摄入量测试时，在最初四周喂食HF饮食的大鼠仍然更喜欢脂肪含量最高的混合物。
