羽扇豆烷型和19β,28-环氧-18α-齐墩果烷型2,3-断三萜腙的抗病毒活性

[Antiviral activity of 2,3-secotriterpenic hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type].

作者信息

Galaĭko N V, Tolmacheva I A, Grishko V V, Volkova L V, Prevozchikova E N, Pestereva S A

出版信息

Bioorg Khim. 2010 Jul-Aug;36(4):556-62.

PMID:20823925

Abstract

Novel hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type have been synthesized via interaction of 2,3-secotriterpenic aldehydonitriles with substituted hydrazines. As a result of investigation of 2,3-secotriterpenic hydrazones antiviral activity to the strain "Indiana" of vesicular stomatitis virus on two models of mammal's line cell infection, acetylhydrazone 1-cyano-2,3-seco-19beta,28-epoxy-18alpha-olean-3-al has been found to have a high prophylactic activity 0.00016 microg/ml to vesicular stomatitis virus and to inhibit a virus reproduction in primarily infected cells in 0.21 microg/ml concentration.

摘要

通过2,3-断三萜醛腈与取代肼的相互作用，合成了羽扇豆烷型和19β,28-环氧-18α-齐墩果烷型的新型腙。在两种哺乳动物系细胞感染模型上，对水泡性口炎病毒“印第安纳”株研究2,3-断三萜腙的抗病毒活性时，发现1-氰基-2,3-断-19β,28-环氧-18α-齐墩果-3-醛乙酰腙对水泡性口炎病毒具有0.00016微克/毫升的高预防活性，并且在浓度为0.21微克/毫升时能抑制病毒在初次感染细胞中的繁殖。