Mizrak Ayse, Erbagci Ibrahim, Arici Tulin, Ozcan Ibrahim, Ganidagli Suleyman, Tatar Gurkan, Oner Unsal
Anesthesiology and Reanimation, Gaziantep University School of Medicine, Gaziantep, Turkey.
Clin Ophthalmol. 2010 Aug 19;4:673-9. doi: 10.2147/opth.s11336.
To compare the effects of intravenous infusion of ketamine and propofol anesthesia in children undergoing strabismus surgery.
Sixty pediatric patients aged 4-11 years were enrolled for the study. Patients in Group K were infused ketamine 1-3 mg/kg/hr (n = 30) and patients in Group P were infused with propofol 6-9 mg/kg/hr (n = 30). After giving fentanyl 1 mug/kg and rocuronium bromide 0.5 mg/kg, patients were intubated.
The consumption of anesthetics (P = 0.0001) and antiemetics (P = 0.004), the incidence of oculocardiac reflex (P = 0.02) in Group K were significantly lower than in Group P. The recovery time (P = 0.008), postoperative agitation score (P = 0.005), Face Pain Scale (P = 0.001), Ramsay Sedation Score (P = 0.01) during awakening and at postoperative 30th min (P = 0.02) in Group K were significantly lower than in Group P. The postoperative agitation score during awakening was significantly lower than the preoperative values in Group K (P = 0.0001).
The infusion of ketamine is more advantageous than the infusion of propofol in children for use in strabismus surgery.
比较氯胺酮和丙泊酚静脉输注麻醉对斜视手术患儿的影响。
纳入60例4 - 11岁的儿科患者进行研究。K组患者以1 - 3 mg/kg/hr的速度输注氯胺酮（n = 30），P组患者以6 - 9 mg/kg/hr的速度输注丙泊酚（n = 30）。给予患者1 μg/kg芬太尼和0.5 mg/kg罗库溴铵后进行插管。
K组的麻醉药消耗量（P = 0.0001）、止吐药消耗量（P = 0.004）以及眼心反射发生率（P = 0.02）均显著低于P组。K组的苏醒时间（P = 0.008）、苏醒期术后躁动评分（P = 0.005）、面部疼痛量表评分（P = 0.001）、Ramsay镇静评分（P = 0.01）以及术后30分钟时的相应评分（P = 0.02）均显著低于P组。K组苏醒期术后躁动评分显著低于术前值（P = 0.0001）。
在儿童斜视手术中，输注氯胺酮比输注丙泊酚更具优势。
