氯胺酮与丙泊酚用于儿童斜视手术的比较。
Ketamine versus propofol for strabismus surgery in children.
作者信息
Mizrak Ayse, Erbagci Ibrahim, Arici Tulin, Ozcan Ibrahim, Ganidagli Suleyman, Tatar Gurkan, Oner Unsal
机构信息
Anesthesiology and Reanimation, Gaziantep University School of Medicine, Gaziantep, Turkey.
出版信息
Clin Ophthalmol. 2010 Aug 19;4:673-9. doi: 10.2147/opth.s11336.
PURPOSE
To compare the effects of intravenous infusion of ketamine and propofol anesthesia in children undergoing strabismus surgery.
METHODS
Sixty pediatric patients aged 4-11 years were enrolled for the study. Patients in Group K were infused ketamine 1-3 mg/kg/hr (n = 30) and patients in Group P were infused with propofol 6-9 mg/kg/hr (n = 30). After giving fentanyl 1 mug/kg and rocuronium bromide 0.5 mg/kg, patients were intubated.
RESULTS
The consumption of anesthetics (P = 0.0001) and antiemetics (P = 0.004), the incidence of oculocardiac reflex (P = 0.02) in Group K were significantly lower than in Group P. The recovery time (P = 0.008), postoperative agitation score (P = 0.005), Face Pain Scale (P = 0.001), Ramsay Sedation Score (P = 0.01) during awakening and at postoperative 30th min (P = 0.02) in Group K were significantly lower than in Group P. The postoperative agitation score during awakening was significantly lower than the preoperative values in Group K (P = 0.0001).
CONCLUSIONS
The infusion of ketamine is more advantageous than the infusion of propofol in children for use in strabismus surgery.
目的
比较氯胺酮和丙泊酚静脉输注麻醉对斜视手术患儿的影响。
方法
纳入60例4 - 11岁的儿科患者进行研究。K组患者以1 - 3 mg/kg/hr的速度输注氯胺酮（n = 30），P组患者以6 - 9 mg/kg/hr的速度输注丙泊酚（n = 30）。给予患者1 μg/kg芬太尼和0.5 mg/kg罗库溴铵后进行插管。
结果
K组的麻醉药消耗量（P = 0.0001）、止吐药消耗量（P = 0.004）以及眼心反射发生率（P = 0.02）均显著低于P组。K组的苏醒时间（P = 0.008）、苏醒期术后躁动评分（P = 0.005）、面部疼痛量表评分（P = 0.001）、Ramsay镇静评分（P = 0.01）以及术后30分钟时的相应评分（P = 0.02）均显著低于P组。K组苏醒期术后躁动评分显著低于术前值（P = 0.0001）。
结论
在儿童斜视手术中，输注氯胺酮比输注丙泊酚更具优势。
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