Nefedova N B, Gordeeva M S, Zuev V A
Vopr Virusol. 1990 Nov-Dec;35(6):456-8.
Inoculation of virus-specific cytotoxic lymphocytes (CTL) to pregnant mice infected with influenza virus was shown to result in a decrease of infectious virus concentration in the lungs and blood of mice as well as in the placentas and fetuses. With an increase in the dose of inoculated CTL, however, premature deliveries with stillbirths were observed as well as deaths of the mice, the highest frequency of fetal deaths being observed after infection of pregnant mice in the first half of pregnancy. It is not excluded that maternal virus-specific CTL played a role in the formation of developmental abnormalities and immunodeficient states in newborns.
将病毒特异性细胞毒性淋巴细胞（CTL）接种到感染流感病毒的怀孕小鼠体内，结果显示小鼠肺部、血液、胎盘和胎儿中的传染性病毒浓度降低。然而，随着接种CTL剂量的增加，观察到早产伴死产以及小鼠死亡，在怀孕前半期感染怀孕小鼠后观察到的胎儿死亡频率最高。不排除母体病毒特异性CTL在新生儿发育异常和免疫缺陷状态的形成中起作用。
