Richter F, Haschke W, Schmidt D, Leichsenring A
Institute of Physiology, Friedrich Schiller University, Jena, G.D.R.
Act Nerv Super (Praha). 1990 Dec;32(4):257-63.
Rabbits with chronically implanted Ag-AgCl electrodes over somatosensory and visual cortex were trained to a modified 'oddball' paradigm with visual stimulation. Event related potentials (ERP) and slow potential shifts (SPS) were recorded. By means of a computer controlled stimulator 'frequent' and 'rare' LED flashes were administered to the eyes of the rabbit. If 'rare' stimuli were reinforced by a weak electrical footshock, negative SPS rose steeper and reached significantly higher amplitudes than in 'frequent' conditions without reinforcement. Different kinds of the follow-up of 'frequent' and 'rare' series were tested. Best effects were obtained, if a session was divided into 3 blocks (3 srs. 'frequent'--5 srs. 'rare' reinforced--2 srs. 'frequent' and probability of 'rare' flashes was 20%. Our present data formed a basis for investigations on the neuronal and glial sources of SPS in rabbits.
在体感和视觉皮层上长期植入银-氯化银电极的兔子，接受了一种经过改良的带有视觉刺激的“oddball”范式训练。记录事件相关电位（ERP）和慢电位变化（SPS）。通过计算机控制的刺激器，向兔子眼睛施加“频繁”和“罕见”的LED闪光。如果“罕见”刺激通过微弱的电足部电击得到强化，负向SPS上升更陡峭，且达到的幅度显著高于无强化的“频繁”条件。对“频繁”和“罕见”系列的不同后续情况进行了测试。如果将一个实验时段分为3个块（3次“频繁”——5次“罕见”强化——2次“频繁”，且“罕见”闪光的概率为20%），则可获得最佳效果。我们目前的数据为研究兔子SPS的神经元和胶质细胞来源奠定了基础。
