Akashi S, Motizuki H
Division of Nephrology, Saitama Children's Medical Center, Japan.
Acta Paediatr Jpn. 1990 Dec;32(6):701-9. doi: 10.1111/j.1442-200x.1990.tb00908.x.
Reference values for the urinary calcium/creatinine ratio (Ca/Cr ratio) in the first morning urine were established in 361 healthy children aged 5 to 15 years, on unrestricted diets. The urinary Ca/Cr ratio in the urine upon arising was independent of sex but dependent upon age. The measurement of the urinary Ca/Cr ratio in the urine upon arising while on unrestricted diets may be a reasonable screening test for elevated calcium excretion. On the basis of the urinary Ca/Cr ratios in the urine upon arising during unrestricted diets and the calciuric response to calcium restricted diets and the oral calcium loading test, idiopathic hypercalciuria (IH) was subclassified into three groups: (1) absorptive hypercalciuria; (2) renal hypercalciuria; (3) dietary hypercalciuria. The pathogenesis of IH is controversial. Our data suggest that disordered 1,25 (OH)2 vitamin D metabolism with excessive urinary phosphate excretion occurs in absorptive hypercalciuria.
在361名5至15岁饮食不受限制的健康儿童中，确定了晨尿中尿钙/肌酐比值（Ca/Cr比值）的参考值。晨起时尿Ca/Cr比值与性别无关，但与年龄有关。在饮食不受限制时测量晨起尿Ca/Cr比值可能是筛查钙排泄增加的合理检测方法。根据饮食不受限制时晨起尿Ca/Cr比值、对钙限制饮食的钙尿反应以及口服钙负荷试验，特发性高钙尿症（IH）被分为三组：（1）吸收性高钙尿症；（2）肾性高钙尿症；（3）饮食性高钙尿症。IH的发病机制存在争议。我们的数据表明，吸收性高钙尿症中存在1,25（OH）2维生素D代谢紊乱伴尿磷酸盐排泄过多的情况。
