De Souza A, Hamon M
Laboratoire de Chimie analytique, Faculté de Pharmacie, Université Fédérale Fluminense, Niteroi RJ, Brésil.
Ann Pharm Fr. 1990;48(1):7-12.
The mild oxidation of diazepam by hydrogen peroxide in neutral medium at room temperature in daylight is reported. The oxidation product has been isolated and purified and its purity determined by thin layer chromatography. It has been identified by spectroscopy, chiefly by infrared and mass spectroscopy. Finally it has been compared, by high pressure liquid chromatography, to the product from an aqueous diazepam solution placed 6 months at room temperature in daylight.
据报道，地西泮在中性介质中于室温及日光下用过氧化氢进行轻度氧化。氧化产物已被分离、纯化，并通过薄层色谱法测定其纯度。已通过光谱学方法进行鉴定，主要是红外光谱和质谱。最后，通过高压液相色谱法将其与在室温及日光下放置6个月的地西泮水溶液的产物进行了比较。
