[Koilocytosis in precancerous conditions and cancer of the vulva].

The incidences of combination of koilocytosis and dysplasias of squamous epithelium of skin-mucous integument of vulva in 120 patients with kraurosis and leukoplakia and 166 patients with carcinoma of external genitalia (at the distance of 3-4 cm from the tumour) are studied. Vulva tissue of 100 women of the same age dying from non-tumourous conditions served as control. The increase of the koilocytosis incidence was observed at various stages of carcinogenesis (slight dysplasia--mild dysplasia--severe dysplasia--preinvasive carcinoma). koilocytes are not found in the invasive carcinoma. It is suggested to consider koilocytosis as one of additional morphologic signs of the risk of vulva carcinoma. The disappearance of koilocytes which are markers of the viral cell alteration in invasive carcinomas allows one to regard a viral damage of the vulva epithelium as one of the cocarcinogenic influences responsible for the development of squamous cell carcinoma.