多巴胺激动剂与奥赛罗综合征。
Dopamine agonists and Othello's syndrome.
机构信息
Department of Neurology, Mayo Clinic, 200 1st Street SW Rochester, MN 55905, USA.
出版信息
Parkinsonism Relat Disord. 2010 Dec;16(10):680-2. doi: 10.1016/j.parkreldis.2010.08.007. Epub 2010 Sep 9.
BACKGROUND
Othello's syndrome (OS) is a delusion of infidelity. We describe seven cases of OS in Parkinson's disease (iPD) patients using dopamine agonists.
METHODS
We searched the Mayo Clinic Medical Records System to identify all patients with OS. Clinical data abstracted include sex, age of onset of iPD, age of onset of OS, medications, effect of discontinuing the dopamine agonist, neuroimaging, and comorbidities.
RESULTS
Seven non-demented iPD patients with dopamine agonist implementation time locked to the development and resolution of OS are reported. The average age of iPD onset was 46.6 years (Standard deviation: 5.0 years), and OS onset was 53.7 years (7.1 years). All seven patients had significant marital conflict as a result of the delusions.
CONCLUSIONS
OS can be associated with dopamine agonist use and can lead to serious consequences. Dopamine agonist cessation eliminates the delusion of infidelity and should be the first treatment option.
背景
奥赛罗综合征（OS）是一种不忠的妄想。我们描述了使用多巴胺激动剂的 7 例帕金森病（iPD）患者的 OS 病例。
方法
我们搜索了梅奥诊所的医疗记录系统，以确定所有 OS 患者。提取的临床数据包括性别、iPD 发病年龄、OS 发病年龄、药物、停用多巴胺激动剂的效果、神经影像学和合并症。
结果
报告了 7 例非痴呆的 iPD 患者，他们的多巴胺激动剂使用时间与 OS 的发生和缓解相吻合。iPD 发病的平均年龄为 46.6 岁（标准差：5.0 岁），OS 发病年龄为 53.7 岁（7.1 岁）。所有 7 名患者都因妄想而产生了严重的婚姻冲突。
结论
OS 可能与多巴胺激动剂的使用有关，并可能导致严重后果。停止使用多巴胺激动剂可以消除不忠的妄想，应作为首选治疗方案。
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