Tombaugh Tom N, Berrigan Lindsay I, Walker Lisa A S, Freedman Mark S
Department of Psychology, Carleton University, Ottawa, Ontario, Canada.
Cogn Behav Neurol. 2010 Sep;23(3):192-8. doi: 10.1097/WNN.0b013e3181cc8bd4.
To compare the ability of the Computerized Test of Information Processing (CTIP) to detect impaired cognitive processing speed in patients with multiple sclerosis (MS) with a traditional 3.0 second Paced Auditory Serial Addition Test (PASAT) and the Adjusting-PASAT which allows for calculation of a speed score.
A primary cognitive deficit in MS is an impaired ability to process information quickly. Unfortunately, relatively few clinical tests effectively measure information processing speed. Of these, the PASAT is generally acknowledged to be the most sensitive, but use of this test is constrained by several factors.
All tests were administered to 30 adults with relapsing-remitting MS and 30 control participants.
A series of analysis of variances revealed MS participants performed significantly worse than controls on the CTIP and the 3.0 second PASAT, whereas no significant difference was observed for the Adjusting-PASAT.
The results suggest the CTIP can detect deficits in the speed at which people with MS process information. Thus, the CTIP offers an alternative means to the 3.0 second PASAT included in the Multiple Sclerosis Functional Composite for assessing such impairment.
比较信息处理计算机化测试（CTIP）与传统的3.0秒听觉序列加法测试（PASAT）以及可计算速度分数的调整PASAT在检测多发性硬化症（MS）患者认知处理速度受损方面的能力。
MS的主要认知缺陷是快速处理信息的能力受损。不幸的是，相对较少的临床测试能有效测量信息处理速度。其中，PASAT通常被认为是最敏感的，但该测试的使用受到几个因素的限制。
对30名复发缓解型MS成年患者和30名对照参与者进行了所有测试。
一系列方差分析显示，MS参与者在CTIP和3.0秒PASAT上的表现明显比对照组差，而调整PASAT未观察到显著差异。
结果表明CTIP可以检测出MS患者处理信息的速度缺陷。因此，CTIP为多发性硬化症功能综合评估中包含的3.0秒PASAT提供了另一种评估此类损伤的方法。
