阿尔茨海默病患者根除幽门螺杆菌后的五年生存率。

Five-year survival after Helicobacter pylori eradication in Alzheimer disease patients.

作者信息

Kountouras Jannis, Boziki Marina, Gavalas Emmanouel, Zavos Christos, Deretzi Georgia, Chatzigeorgiou Stavros, Katsinelos Panagiotis, Grigoriadis Nikolaos, Giartza-Taxidou Evangelia, Venizelos Ioannis

机构信息

Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Byzantio, Thessaloniki, Macedonia, Greece.

出版信息

Cogn Behav Neurol. 2010 Sep;23(3):199-204. doi: 10.1097/WNN.0b013e3181df3034.

DOI:10.1097/WNN.0b013e3181df3034

PMID:20829670

Abstract

BACKGROUND

Alzheimer disease (AD) is a progressive, fatal neurodegenerative condition.

OBJECTIVE

We tested the hypothesis that eradication of Helicobacter pylori infection (Hp-I) could improve survival in a Greek cohort of AD patients, in a 5-year follow-up.

METHOD

Forty-six patients diagnosed with probable AD were enrolled in the analysis. Study population was classified into 3 groups: patients for whom Hp eradication treatment was successful; those for whom eradication of Hp had failed, they refused, and/or were noncompliant with eradication therapy; and those who were Hp negative at baseline. Cox proportional hazards model was built with all-cause mortality as the dichotomous outcome.

RESULTS

During the 5-year follow-up [47.19±15.11 mo (range 12 to 60)], overall 21 patients died and 25 patients remained alive. Patients who died were older and exhibited lower mean MMSE score compared with the patients still alive. Successful eradication of Hp-I was associated with a significantly lower mortality risk [HR (95% CI)=0.287 (0.114-0.725), P=0.008]. The results were similar in adjusted and unadjusted models, for age and MMSE at baseline.

CONCLUSION

Hp eradication regimen in AD patients is associated with a higher 5-year survival rate.

摘要

背景

阿尔茨海默病（AD）是一种进行性致命性神经退行性疾病。

目的

我们检验了这样一个假设，即在希腊的一组AD患者中，根除幽门螺杆菌感染（Hp-I）可在5年随访期内提高生存率。

方法

46例被诊断为可能患有AD的患者纳入分析。研究人群分为3组：Hp根除治疗成功的患者；Hp根除失败、拒绝治疗和/或未遵行根除治疗的患者；以及基线时Hp阴性的患者。构建以全因死亡率为二分结局的Cox比例风险模型。

结果

在5年随访期内[47.19±15.11个月（范围12至60个月）]，共有21例患者死亡，25例患者存活。与仍存活的患者相比，死亡患者年龄更大，平均MMSE评分更低。成功根除Hp-I与显著降低的死亡风险相关[风险比（95%置信区间）=0.287（0.114 - 0.725），P = 0.008]。在根据基线年龄和MMSE进行调整和未调整的模型中，结果相似。