Department of Radiology, Medical Imaging Centre, Tampere University Hospital, Tampere, Finland.
Invest Radiol. 2010 Dec;45(12):795-802. doi: 10.1097/RLI.0b013e3181ec9c96.
To compare quantitatively T2- and T2*-based magnetic resonance imaging sequences in patients with symptoms of Parkinson disease and to evaluate the information content of those sequences regarding brain iron concentration.
We imaged 51 patients with symptoms of Parkinson disease on 3-T magnetic resonance imaging with T2-weighted sampling perfection with application optimized contrasts using different flip-angle evolution (SPACE), fluid attenuation inversion recovery (FLAIR)-SPACE, susceptibility-weighted imaging (SWI), and parametric T2* sequence (MapIt). Signal analysis was performed in 22 regions of interest in the brain.
Correlations (r2 = 0.82...0.96) with brain iron concentration were excellent. Contrast and tissue separability ratios were best in the T2* maps and FLAIR-SPACE, respectively. Good correlations of contrast were reached between SWI and both T2-weighted SPACE and FLAIR-SPACE. Their relation to quantitative T2* values was reminiscent of a quadratic curve shape. However, separation into gray and white matter revealed a linear positive and negative correlation, respectively.
SWI showed potential in differentiating illnesses characterized by brain iron deposition. Closely similar information was given by T2-weighted SPACE and FLAIR-SPACE, whereas other sequence comparisons revealed dispersion from intersequence agreement.
比较基于 T2 和 T2*的磁共振成像序列在帕金森病症状患者中的定量表现，并评估这些序列在脑铁浓度方面的信息含量。
我们对 51 例有帕金森病症状的患者在 3T 磁共振成像上进行了成像，采用不同翻转角演化的 T2 加权采样完美对比应用（SPACE）、液体衰减反转恢复（FLAIR）-SPACE、磁敏感加权成像（SWI）和参数 T2*序列（MapIt）。在大脑的 22 个感兴趣区域进行信号分析。
与脑铁浓度的相关性（r2=0.82...0.96）非常好。T2图和 FLAIR-SPACE 的对比度和组织可分离性比值最好。SWI 与 T2 加权 SPACE 和 FLAIR-SPACE 之间的对比度具有良好的相关性。它们与定量 T2值的关系类似于二次曲线形状。然而，灰白质的分离分别呈现出线性正相关和负相关。
SWI 在区分以脑铁沉积为特征的疾病方面具有潜力。T2 加权 SPACE 和 FLAIR-SPACE 提供了非常相似的信息，而其他序列比较则显示出序列间一致性的离散性。
