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肥胖症患者(BMI≥35kg/m²)接受减重手术后对糖尿病的临床获益所产生的经济影响。

Economic impact of the clinical benefits of bariatric surgery in diabetes patients with BMI ≥35 kg/m².

机构信息

Division of Gastroenterology, Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.

出版信息

Obesity (Silver Spring). 2011 Mar;19(3):581-7. doi: 10.1038/oby.2010.199. Epub 2010 Sep 9.

Abstract

The medical costs for a type 2 diabetes patient are two to four times greater than the costs for a patient without diabetes. Bariatric surgery is the most effective weight-loss therapy and has marked therapeutic effects on diabetes. We estimate the economic effect of the clinical benefits of bariatric surgery for diabetes patients with BMI ≥ 35 kg/m². Using an administrative claims database of privately insured patients covering 8.5 million lives 1999-2007, we identify obese patients with diabetes, aged 18-65 years, who were treated with bariatric surgery identified using Healthcare Common Procedure Coding System codes. These patients were matched with nonsurgery control patients on demographic factors, comorbidities, and health-care costs. The overall return on investment (RoI) associated with bariatric surgery was calculated using multivariate analysis. Surgery and control patients were compared postindex with respect to diagnostic claims for diabetes, diabetes medication claims, and adjusted diabetes medication and supply costs. Surgery costs were fully recovered after 26 months for laparoscopic surgery. At month 6, 28% of surgery patients had a diabetes diagnosis, compared to 74% of control patients (P < 0.001). Among preindex insulin users, insulin use dropped to 43% by month 3 for surgery patients, vs. 84% for controls (P < 0.001). By month 1, medication and supply costs were significantly lower for surgery patients (P < 0.001). The therapeutic benefits of bariatric surgery on diabetes translate into considerable economic benefits. These data suggest that surgical therapy is clinically more effective and ultimately less expensive than standard therapy for diabetes patients with BMI ≥ 35 kg/m².

摘要

2 型糖尿病患者的医疗费用比非糖尿病患者高出 2 至 4 倍。减重手术是最有效的减肥疗法,对糖尿病有显著的治疗作用。我们评估了肥胖症患者(BMI≥35kg/m²)接受减重手术对糖尿病的临床获益的经济影响。我们利用了一个覆盖 1999 年至 2007 年 850 万份私人保险患者的行政索赔数据库,识别出接受了减重手术的糖尿病肥胖症患者(年龄在 18-65 岁之间),并使用医疗保健通用程序编码系统(Healthcare Common Procedure Coding System)代码对其进行了识别。根据人口统计学因素、合并症和医疗保健费用,这些患者与非手术对照组患者进行了匹配。使用多变量分析计算了与减重手术相关的总体投资回报率(RoI)。术后,我们比较了手术组和对照组患者的糖尿病诊断、糖尿病药物使用、调整后的糖尿病药物和供应费用。腹腔镜手术在 26 个月后完全收回了手术成本。在第 6 个月,28%的手术患者被诊断患有糖尿病,而对照组患者为 74%(P<0.001)。在术前使用胰岛素的患者中,手术患者的胰岛素使用量在第 3 个月降至 43%,而对照组患者为 84%(P<0.001)。从第 1 个月开始,手术患者的药物和供应费用显著降低(P<0.001)。减重手术对糖尿病的治疗益处转化为可观的经济效益。这些数据表明,对于 BMI≥35kg/m²的糖尿病患者,手术治疗在临床上更有效,最终比标准治疗更便宜。

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