Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
Korean J Intern Med. 2010 Sep;25(3):331-6. doi: 10.3904/kjim.2010.25.3.331. Epub 2010 Aug 31.
We experienced a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by immunohistochemistry and molecular testing of SYT-SSX2 fusion transcripts. The patient was a 61-year-old man who presented with a well-defined mass in the left upper lung field on chest radiography. Left upper lobectomy with lymph node dissection was performed. Histological and immunophenotypic features were consistent with biphasic synovial sarcoma. Reverse transcriptase polymerase chain reaction, performed using RNA extracted from frozen tumor samples for the detection of SYT-SSX fusion gene, amplified a single 331-bp fragment that was characteristic of the SYT-SSX2 fusion transcripts. We report a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by SYT-SSX2 fusion transcripts, and present a brief review of the literature on Korean cases.
我们遇到了一例原发性肺双相滑膜肉瘤，通过 SYT-SSX2 融合转录本的免疫组织化学和分子检测得到证实。患者为 61 岁男性，胸部 X 线检查显示左肺上野有界限清楚的肿块。行左肺上叶切除术及淋巴结清扫术。组织学和免疫表型特征与双相滑膜肉瘤一致。使用从冷冻肿瘤样本中提取的 RNA 进行逆转录聚合酶链反应，检测 SYT-SSX 融合基因，扩增出 331bp 的单一片段，这是 SYT-SSX2 融合转录本的特征。我们报告了一例原发性肺双相滑膜肉瘤，该肿瘤通过 SYT-SSX2 融合转录本得到证实，并对韩国病例的文献进行了简要回顾。
