Kneczke M, Rahm C, Landersjö L
Apoteksbolaget AB, Central Laboratory, Stockholm, Sweden
Acta Pharm Nord. 1990;2(5):313-8.
A diffusion cell with an artificial membrane (dialysis membrane) was used to study the in vitro release of antralin from an o/w cream (Locobase) in the presence of salicylic acid. The concentration range of antralin was 0.04-3.0%. The influence of salicylic acid on the in vitro release was studied by adding 0.5-3.0% salicylic acid to the creams. Addition of salicylic acid improves the solubility of anthralin in water and probably also in the aqueous phase of the cream. It may also have an effect on the microviscosity of the cream as the structure of the cream changes. Both these factors promoted the in vitro release of antralin. There was also an improvement in clinical efficacy when salicylic acid was added. In this case, the results also can be explained by an isolated effect on the permeability of the stratum corneum.
使用带有人工膜（透析膜）的扩散池，在水杨酸存在的情况下，研究蒽林从水包油乳膏（Locobase）中的体外释放。蒽林的浓度范围为0.04 - 3.0%。通过向乳膏中添加0.5 - 3.0%的水杨酸，研究水杨酸对体外释放的影响。添加水杨酸可提高蒽林在水中以及可能在乳膏水相中的溶解度。随着乳膏结构的变化，它也可能对乳膏的微粘度产生影响。这两个因素都促进了蒽林的体外释放。添加水杨酸时临床疗效也有所改善。在这种情况下，结果也可以通过对角质层渗透性的单独作用来解释。
