Fyllingen G, Langvik T A, Hasselgård P, Roksvaag P O
Military Pharmaceutical Laboratory, Joint Medical Service, Oslo, Norway.
Acta Pharm Nord. 1990;2(5):355-62.
Adrenaline injection fluids aged between 3 and 33 years were analyzed with respect to oxidation and racemization. The oxidation was determined by ion-pair reversed phase HPLC, and the degree of racemization was determined by derivatization of the adrenaline isomers to diastereomeric forms and subsequently separated by reversed phase HPLC. 10% adrenaline was oxidized after about 11 years, while 10% L-adrenaline was converted to D-adrenaline after only 4 years. After about 4 years, the injections contained less than 90% active adrenaline.
对3至33年的肾上腺素注射液进行了氧化和消旋化分析。氧化通过离子对反相高效液相色谱法测定，消旋化程度通过将肾上腺素异构体衍生为非对映体形式并随后通过反相高效液相色谱法分离来测定。10%的肾上腺素在大约11年后被氧化，而10%的L-肾上腺素仅在4年后就转化为D-肾上腺素。大约4年后，注射液中活性肾上腺素含量低于90%。
