高稳定性和可溶性双水合 Gd、Nd、Yb 配合物作为潜在的双模式 MRI/NIR 成像剂。
Highly stable and soluble bis-aqua Gd, Nd, Yb complexes as potential bimodal MRI/NIR imaging agents.
机构信息
Laboratoire de Reconnaissance Ionique et Chimie de Coordination, SCIB, (UMR-E 3 CEA-UJF), Institut Nanosciences et Cryogénie, INAC, CEA-Grenoble, 17 rue des Martyrs, 38054, Grenoble Cedex 09, France.
出版信息
Dalton Trans. 2010 Oct 28;39(40):9490-2. doi: 10.1039/c0dt00994f. Epub 2010 Sep 7.
A tripodal ligand based on the 8-hydroxyquinolinate binding unit yields a soluble and highly stable bis-hydrated Gd(3+) complex in water (pGd = 19.2(3)) with relaxivity change in the pH range 4.5-7.4 and Nd(3+), Yb(3+) analogues with sizeable NIR emission upon excitation at 370 nm providing a new architecture for the development of bimodal agents.
一种基于 8-羟基喹啉结合单元的三足配体在水中生成一种可溶性和高稳定的双水合 Gd(3+)配合物（pGd = 19.2(3)），在 pH 值 4.5-7.4 范围内具有弛豫率变化，Nd(3+)、Yb(3+)类似物在 370nm 激发下具有可观的近红外发射，为双模态试剂的开发提供了一种新的结构。
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