Kenan and Caudill Laboratories of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Org Lett. 2010 Oct 1;12(19):4416-9. doi: 10.1021/ol101961c.
The enantioselective total synthesis of spirofungins A (1) and B (2) is reported in 14 steps over the longest linear sequence. Key steps include the use of thiazolidinethione-mediated aldol reactions to assemble the major fragments and installation of the C1-C6 side chain using a cross metathesis reaction.
本文报道了以最长线性序列通过 14 步反应完成了对 spirofungin A(1)和 B(2)的对映选择性全合成。关键步骤包括使用噻唑烷-4-硫酮介导的 aldol 反应来组装主要片段,以及使用交叉复分解反应来安装 C1-C6 侧链。