Baba Yosuke, Ishikawa Shizukiyo, Kayaba Kazunori, Gotoh Tadao, Kajii Eiji
Haga Red Cross Hospital, 2461 Dai-machi, Moka, Tochigi, Japan.
Blood Press. 2011 Feb;20(1):10-4. doi: 10.3109/08037051.2010.516075. Epub 2010 Sep 13.
The relationship between pulse pressure (PP) and stroke has been described in populations outside Japan. Here, we investigated the relationship between PP and stroke incidence in Japan.
Study subjects were 11,097 people (4315 men and 6782 women) in 12 rural areas of Japan enrolled in the Jichi Medical School Cohort Study, a population-based prospective study. The subjects were divided into quintiles of PP. Baseline data were obtained by questionnaire and health checkups between April 1992 and July 1995, and the incidence of all strokes and stroke subtypes was monitored.
A total of 412 strokes were observed during a mean follow-up period of 10.7 years. After adjusting for age, smoking status, drinking status, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, body mass index and diabetes mellitus, hazard ratios [HRs] in the second to fifth quintiles of PP for all strokes were 1.06 (95% confidence interval [CI] 0.69-1.64), 1.53 (CI 1.02-2.28), 2.02 (CI 1.38-2.96) and 2.22 (CI 1.53-3.20) compared with the first quintile using Cox's proportional hazard model, respectively.
Our findings suggest high PP is at an increased risk of stroke.
脉压（PP）与中风之间的关系在日本以外的人群中已有描述。在此，我们调查了日本人群中PP与中风发病率之间的关系。
研究对象为参加自治医科大学队列研究的日本12个农村地区的11,097人（男性4315人，女性6782人），这是一项基于人群的前瞻性研究。将研究对象按PP五分位数分组。通过问卷调查和1992年4月至1995年7月期间的健康检查获取基线数据，并监测所有中风及中风亚型的发病率。
在平均10.7年的随访期内共观察到412例中风。在调整年龄、吸烟状况、饮酒状况、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、体重指数和糖尿病后，使用Cox比例风险模型，PP第二至第五五分位数组与第一五分位数组相比，所有中风的风险比[HRs]分别为1.06（95%置信区间[CI]0.69 - 1.64）、1.53（CI 1.02 - 2.28）、2.02（CI 1.38 - 2.96）和2.22（CI 1.53 - 3.20）。
我们的研究结果表明，高PP会增加中风风险。
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