Biology Department, Vassar College, 124 Raymond Ave., Box 70, Poughkeepsie, NY, 12604, USA.
Cardiovascular Engineering, Inc., 1 Edgewater Drive, Suite 201A, Norwood, MA, 02062, USA.
Curr Hypertens Rep. 2019 Feb 21;21(2):19. doi: 10.1007/s11906-019-0919-x.
The review discusses evidence from the Framingham Heart Study that supports the assessment and utility of novel vascular and blood pressure measures to inform clinical management of blood pressure-related cardiovascular disease.
Recent Framingham Heart Study investigations provide new insights into the associations of novel and traditional vascular and blood pressure measures, such as measures of aortic stiffness, components of blood pressure waves, and orthostatic change in blood pressure, with cardiovascular disease events and brain structure and function. Novel vascular measures provide opportunities for additional investigation and potential development of new interventions that are more precisely targeted at underlying pathophysiology. Inclusion of novel vascular measures should be considered in clinical practice to screen for early, subclinical disease and to stratify high-risk individuals for targeted therapies.
本综述讨论了弗雷明汉心脏研究的证据，该证据支持评估和利用新型血管和血压指标，以告知与血压相关的心血管疾病的临床管理。
最近的弗雷明汉心脏研究调查提供了新的见解，了解新型和传统的血管和血压指标（如主动脉僵硬度、血压波成分和血压的体位变化）与心血管疾病事件以及大脑结构和功能之间的关联。新型血管指标为进一步研究和潜在开发更针对潜在病理生理学的新干预措施提供了机会。在临床实践中应考虑纳入新型血管指标，以筛查早期亚临床疾病，并对高危人群进行靶向治疗。
