Xylinas E, Le Gal S, Descazeaud A
Service d'urologie, hôpital Cochin Port-Royal, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Prog Urol. 2010 Sep;20(8):566-71. doi: 10.1016/j.purol.2010.05.003. Epub 2010 Jun 29.
Benign prostatic hyperplasia (BPH) is a common disease affecting a large proportion of men older than 50 years. There are multiple treatment options for BPH including medications, minimally invasive options such as transurethral needle ablation (Tuna) and transurethral microwave therapy (TUMT), and more invasive options such as transurethral laser vaporization and transurethral resection of the prostate (TURP). The minimally invasive options induce thermal injury to the BPH adenoma with a lower risk of permanent side effects than TURP. Tuna treatment is a minimally invasive technique of BPH which can be carried out in ambulatory surgery and which is effective for urinary symptoms with little risk of morbidity. It is an alternative to medical treatment and does not replace planned surgical treatment. Available evidence suggests that Tuna is a relatively effective and safe technique. It significantly improves BPH parameters but it does not reach the same level efficacy and long-lasting success as TURP. Also the Tuna procedure compares favourably to combination medical therapy for the treatment of BPH on a cost basis. α-Blocker monotherapy is less costly than Tuna for 5 years, while the cost of 5α-reductase inhibitor monotherapy is approximately equivalent to that of Tuna for 5 years. From the payer's perspective, the break-even point between the Tuna(®) procedure and combination medical management occurs after approximately 2 years 7 months of treatment.
良性前列腺增生(BPH)是一种常见疾病,影响着很大比例的50岁以上男性。BPH有多种治疗选择,包括药物治疗、微创治疗,如经尿道针刺消融术(TUNA)和经尿道微波热疗(TUMT),以及更具侵入性的治疗,如经尿道激光汽化术和经尿道前列腺切除术(TURP)。微创治疗对BPH腺瘤造成热损伤,与TURP相比,永久性副作用风险更低。TUNA治疗是一种BPH的微创技术,可在门诊手术中进行,对尿路症状有效,发病风险小。它是药物治疗的替代方法,但不能取代计划性手术治疗。现有证据表明,TUNA是一种相对有效且安全的技术。它能显著改善BPH相关参数,但疗效和长期成功率未达到TURP的水平。此外,在成本方面,TUNA手术与BPH联合药物治疗相比具有优势。α受体阻滞剂单药治疗5年的成本低于TUNA,而5α还原酶抑制剂单药治疗5年的成本与TUNA大致相当。从支付方的角度来看,TUNA手术与联合药物治疗的收支平衡点出现在治疗约2年7个月后。