Institut für Neurobiologie, Universität Münster, Badestr. 9, 48149 Münster, Germany.
Curr Opin Neurobiol. 2011 Feb;21(1):11-6. doi: 10.1016/j.conb.2010.08.011. Epub 2010 Sep 9.
Trans-cellular communication relies on a complex interplay of cell-cell adhesion and signaling induced by diffusible molecules. This is particularly evident for neuron-glia interaction in the nervous system. The small, relative number of glial cells in combination with well-established genetic techniques predestines Drosophila as a powerful model to dissect the molecular basis of neuron-glia interaction. We are discussing homophilic and heterophilic adhesion systems that ensure proper interaction of neurons and glial cells as well as prominent signaling cascades regulating various aspects of coordinated neuron-glial development. The combination of these results in instructive signals governing proper nervous system development and function.
细胞间通讯依赖于可扩散分子诱导的细胞-细胞黏附和信号的复杂相互作用。这在神经系统中的神经元-胶质细胞相互作用中尤为明显。少量相对的胶质细胞与成熟的遗传技术相结合，使果蝇成为一个强大的模型，可以剖析神经元-胶质细胞相互作用的分子基础。我们正在讨论同亲性和异亲性黏附系统，这些系统确保了神经元和胶质细胞的正常相互作用，以及调节协调的神经元-胶质发育各个方面的显著信号级联反应。这些结果的结合产生了指导信号，控制着神经系统的正常发育和功能。
