Verderio Claudia, Matteoli Michela
CNR Institute of Neuroscience and Department of Medical Pharmacology, Università degli Studi di Milano, via Vanvitelli, 32 - 20129 Milan, Italy.
Brain Res Rev. 2011 Jan 7;66(1-2):106-14. doi: 10.1016/j.brainresrev.2010.04.007. Epub 2010 May 6.
ATP accomplishes important roles in brain, where it functions as neurotransmitter or co-transmitter, being stored and released either as single mediator or together with other neuromodulators. In the last years, the purinergic system has emerged as the most relevant mechanism for intercellular signalling in the nervous system, affecting communication between many types of neurons and all types of glia. In this review, we will focus on recently reported data which describe the role of ATP in bidirectional signalling between neurons and different populations of glial cells, in both peripheral and central system.
ATP在大脑中发挥着重要作用，它作为神经递质或共递质发挥功能，以单一介质或与其他神经调质一起储存和释放。在过去几年中，嘌呤能系统已成为神经系统中细胞间信号传导最相关的机制，影响多种类型神经元和所有类型神经胶质细胞之间的通讯。在本综述中，我们将重点关注最近报道的数据，这些数据描述了ATP在周围和中枢系统中神经元与不同神经胶质细胞群体之间双向信号传导中的作用。
