The Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Douglas Campus, Townsville, QLD 4811, Australia.
Atherosclerosis. 2011 Feb;214(2):237-43. doi: 10.1016/j.atherosclerosis.2010.08.051. Epub 2010 Aug 19.
Abdominal aortic aneurysm (AAA) and atherosclerosis are common causes of mortality and morbidity in an aging population. Angiogenesis is believed to contribute to the development and progression of these diseases. Angiopoietins (angpts) are known to be important regulators of angiogenesis. Angpts can also influence inflammation and have been shown to possess both pro-atherosclerotic and atheroprotective effects. This review explores the potential roles that the angpts play in the development and progression of AAA and atherosclerosis.
腹主动脉瘤 (AAA) 和动脉粥样硬化是老龄化人口中导致死亡和发病的常见原因。血管生成被认为有助于这些疾病的发展和进展。已知血管生成素 (angpts) 是血管生成的重要调节剂。血管生成素还可以影响炎症,并且已显示出具有促动脉粥样硬化和抗动脉粥样硬化作用。本综述探讨了血管生成素在 AAA 和动脉粥样硬化发展和进展中可能发挥的作用。