细胞视角下的 NF2 在肝脏稳态和肿瘤发生中的作用

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Dev Cell. 2010 Sep 14;19(3):363-4. doi: 10.1016/j.devcel.2010.08.015.

How liver adjusts and stabilizes its size is unsolved so far; the answers to this question may also provide insights into mechanisms of hepatocarcinogenesis. Two recent papers suggest a role for Merlin/Nf2 in control of liver cell turnover, but results appear conflicting at first glance.

迄今为止，肝脏如何调节和稳定其大小仍是未解之谜；对这个问题的解答也可能为肝癌发生机制提供新的见解。最近的两篇论文提示 Merlin/Nf2 可能在控制肝细胞更新中发挥作用，但乍一看结果似乎相互矛盾。