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[荧光染料在人体肿瘤细胞和正常细胞中的积聚]

[Accumulation of fluorescent dyes in tumor and normal cells of man].

作者信息

Tankovich N I, Revazova E S, Osokina L I, Iudicheva B V, Baranov E P, Kozorez A B

出版信息

Biull Eksp Biol Med. 1990 Dec;110(12):641-3.

PMID:2083370
Abstract

The comparative accumulation of fluorescein Na2-salt (FINa) by the established cell lines of human tumors (cancer of the uterine body, urinary bladder, Wilms tumor, chorionepithelioma, melanoma, rhabdomyosarcoma, osteosarcoma) and human normal fibroblast cultures was obtained. The tumor cells of the different genesis is characterized by its own parameters of FINa accumulation. The most pronounced accumulation of dye has been noted for cells of cancer of the uterine body, the urinary bladder and chorionepithelioma. The normal cells accumulated FINa less considerably. Mechanism of the selective accumulation of dye by the tumor cells was discussed.

摘要

对人肿瘤(子宫体癌、膀胱癌、肾母细胞瘤、绒毛膜上皮癌、黑色素瘤、横纹肌肉瘤、骨肉瘤)的已建细胞系和人正常成纤维细胞培养物中荧光素钠(FINa)的积累情况进行了比较。不同起源的肿瘤细胞具有其自身的FINa积累参数。已观察到子宫体癌、膀胱癌和绒毛膜上皮癌的细胞对染料的积累最为明显。正常细胞积累FINa的程度较低。文中讨论了肿瘤细胞对染料选择性积累的机制。

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