Second Department of Cardiology, Nikea General Hospital, Athens, Greece.
Angiology. 2011 May;62(4):310-6. doi: 10.1177/0003319710382418. Epub 2010 Sep 11.
We investigated the role of high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and N-terminal pro-brain natriuretic peptide (NTpro-BNP), in atrial fibrillation (AF) recurrence rate.
A total of 80 patients with first AF episode were studied prospectively. Echocardiography (ECG), Holter ECG, and measurements of hsCRP, IL-6, and NTproBNP were performed immediately post conversion and at 1 month.
Recurrence was positively related to left atrial volume (P < .001), with no difference in NTpro-BNP, hsCRP, and IL-6. Decreased NTpro-BNP was observed in all at 1 month (P < .001, F = 63.4) and was positively related to left atrial volume (P < .01). In the lone AF subgroup, NTpro-BNP was lower and dropped significantly at 1 month (interaction F = 6.53, P < .01).
Atrial volume was related to AF recurrence, whereas hsCRP, IL-6, and NTpro-BNP were not reliable for AF relapse. Relation of NTpro-BNP to left atrial volume could indicate a role in the atrial remodeling process.
我们研究了高敏 C 反应蛋白（hsCRP）、白细胞介素 6（IL-6）和 N 端脑利钠肽前体（NTpro-BNP）在心房颤动（AF）复发率中的作用。
前瞻性研究了 80 例首次发生 AF 的患者。即刻转换后和 1 个月时进行心电图（ECG）、动态心电图和 hsCRP、IL-6 和 NTproBNP 的测量。
复发与左心房容积呈正相关（P<0.001），NTpro-BNP、hsCRP 和 IL-6 无差异。所有患者在 1 个月时 NTpro-BNP 均下降（P<0.001，F=63.4），且与左心房容积呈正相关（P<0.01）。在孤立性 AF 亚组中，NTpro-BNP 较低且在 1 个月时显著下降（交互 F=6.53，P<0.01）。
心房容积与 AF 复发相关，而 hsCRP、IL-6 和 NTpro-BNP 对 AF 复发不可靠。NTpro-BNP 与左心房容积的关系可能表明其在心房重构过程中的作用。
