肢端肥大症患者血清心型脂肪酸结合蛋白水平。

Serum heart-type fatty acid binding protein levels in acromegaly patients.

机构信息

Department of Endocrinology and Metabolism, Dıskapı Y.B. Education and Research Hospital, Ministry of Health, Ankara, Turkey.

出版信息

J Endocrinol Invest. 2011 Sep;34(8):576-9. doi: 10.3275/7259. Epub 2010 Sep 9.

DOI:10.3275/7259

PMID:20834198

Abstract

BACKGROUND

Heart-type fatty acid-binding protein (H-FABP) is a major cytoplasmic low molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is closely associated with acute coronary syndrome, hypertrophic and dilated cardiomyopathy, heart failure, stroke, obstructive sleep apnea syndrome, and pulmonary embolism. The aim of this study was to investigate serum H-FABP value in patients with acromegaly.

METHODS AND RESULTS

We measured serum H-FABP levels in 30 consecutive patients with acromegaly, and 55 age-matched control subjects by using a sandwich enzymelinked immunosorbent assay. Serum H-FABP levels were significantly higher in patients with acromegaly than in control subjects (17.40 ± 10.70, and 8.30 ± 7.20, respectively) (p<0.001). A significant positive correlation was found by Spearman's correlation test between serum H-FABP levels and left ventricular end-systolic diameter (r=0.483, p=0.004).

CONCLUSION

Patients with acromegaly have increased levels of H-FABP. Serum H-FABP levels might be a marker of myocardial performance in patients with acromegaly.

摘要

背景

心脏型脂肪酸结合蛋白（H-FABP）是一种主要的细胞质低分子量蛋白，当心肌受损时会释放到循环中。先前的研究表明，H-FABP与急性冠状动脉综合征、肥厚型和扩张型心肌病、心力衰竭、中风、阻塞性睡眠呼吸暂停综合征和肺栓塞密切相关。本研究旨在探讨肢端肥大症患者血清 H-FABP 值。

方法和结果

我们使用夹心酶联免疫吸附试验测量了 30 例连续肢端肥大症患者和 55 名年龄匹配的对照组的血清 H-FABP 水平。肢端肥大症患者的血清 H-FABP 水平明显高于对照组（分别为 17.40±10.70 和 8.30±7.20）（p<0.001）。Spearman 相关检验显示，血清 H-FABP 水平与左室收缩末期直径呈显著正相关（r=0.483，p=0.004）。