Akbal Erdem, Koçak Erdem, Akyürek Ömer, Köklü Seyfettin, Batgi Hikmetullah, Şenes Mehmet
Department of Gastroenterology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Department of Gastroenterology, Çanakkale State Hospital, Çanakkale, Turkey.
Wien Klin Wochenschr. 2016 Jan;128(1-2):48-52. doi: 10.1007/s00508-014-0680-8. Epub 2014 Dec 2.
Liver fatty acid-binding protein (L-FABP) is a small cytoplasmic protein. The aim of the current study was to investigate L-FABP levels and to determine their diagnostic value for non-alcoholic fatty liver disease (NAFLD).
We enrolled in this study 24 consecutive patients with NAFLD who were diagnosed with elevated transaminases and with steatosis by ultrasonograph. The control group consisted of 22 healthy control subjects matched for age and gender. Serum levels of L-FABP were determined by enzyme-linked immunosorbent assay.
L-FABP levels in NAFLD patients were higher than in the control group (levels were 41,976 ± 18,998 and 17048 ± 5021 pg/mL, respectively). A strong correlation was found between serum L-FABP concentrations and aspartate aminotransferase, alanine aminotransferase, body mass index, glucose and γ-glutamyltransferase levels. A level of 284,000 pg/mL L-FABP had 73% sensitivity and 100% specificity. Positive and negative predictive values for L-FABP were 100 and 79%, respectively.
Serum L-FABP can be considered as a new diagnostic marker for detecting non-alcoholic fatty liver disease.
肝脏脂肪酸结合蛋白（L-FABP）是一种小的细胞质蛋白。本研究的目的是调查L-FABP水平，并确定其对非酒精性脂肪性肝病（NAFLD）的诊断价值。
我们连续纳入了24例经超声检查诊断为转氨酶升高和脂肪变性的NAFLD患者。对照组由22名年龄和性别匹配的健康对照者组成。采用酶联免疫吸附测定法测定血清L-FABP水平。
NAFLD患者的L-FABP水平高于对照组（分别为41,976±18,998和17,048±5,021 pg/mL）。血清L-FABP浓度与天冬氨酸转氨酶、丙氨酸转氨酶、体重指数、血糖和γ-谷氨酰转移酶水平之间存在强相关性。L-FABP水平为284,000 pg/mL时，敏感性为73%，特异性为100%。L-FABP的阳性预测值和阴性预测值分别为100%和79%。
血清L-FABP可被视为检测非酒精性脂肪性肝病的一种新的诊断标志物。
