Department of Anesthesia and Critical Care, Heart Institute, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, Brazil, SP.
Clinics (Sao Paulo). 2010 Jun;65(8):793-8. doi: 10.1590/s1807-59322010000800009.
Spinal anesthesia for cesarean delivery may cause severe maternal hypotension and a decrease in cardiac output. Compared to assessment of cardiac output via a pulmonary artery catheter, the FloTrac/Vigileo system may offer a less invasive technique. The aim of this study was to evaluate cardiac output and other hemodynamic measurements made using the FloTrac/Vigileo system in patients undergoing spinal anesthesia for elective cesarean section.
A prospective study enrolling 10 healthy pregnant women was performed. Hemodynamic parameters were continuously obtained at 15 main points: admission to surgery (two baseline measurements), after preload, after spinal anesthesia administration and 4 time points thereafter (4, 6, 8 and 10 min after anesthesia), at skin and uterine incision, newborn and placental delivery, oxytocin administration, end of surgery, and recovery from anesthesia. Hemodynamic therapy was guided by mean arterial pressure, and vasopressors were used as appropriate to maintain baseline values. A repeated measures ANOVA was used for data analysis.
There was a significant increase in heart rate and a decrease of stroke volume and stroke volume index up to 10 min after spinal anesthesia (P < 0.01). Importantly, stroke volume variation increased immediately after newborn delivery (P < 0.001) and returned to basal values at the end of surgery. Further hemodynamic parameters showed no significant changes over time.
No significant hemodynamic effects, except for heart rate and stroke volume changes, were observed in pregnant women managed with preload and vasopressors when undergoing elective cesarean section and spinal anesthesia.
剖宫产时行椎管内麻醉可能会导致产妇严重低血压和心输出量降低。与肺动脉导管评估心输出量相比,FloTrac/Vigileo 系统可能提供一种侵入性更小的技术。本研究旨在评估行择期剖宫产术的产妇行椎管内麻醉时使用 FloTrac/Vigileo 系统测量的心输出量和其他血流动力学参数。
进行了一项前瞻性研究,共纳入 10 例健康孕妇。在 15 个主要时间点连续获得血流动力学参数:手术入院(两次基线测量)、预负荷后、椎管内麻醉给药后以及麻醉后 4 个时间点(麻醉后 4、6、8 和 10 分钟)、皮肤和子宫切开时、新生儿和胎盘娩出时、催产素给药时、手术结束时和麻醉恢复时。根据平均动脉压指导血流动力学治疗,并酌情使用血管加压药以维持基线值。采用重复测量方差分析进行数据分析。
椎管内麻醉后 10 分钟内,心率显著增加,每搏量和每搏量指数降低(P < 0.01)。重要的是,新生儿娩出后立即出现了搏量变异增加(P < 0.001),并在手术结束时恢复到基础值。进一步的血流动力学参数在整个过程中没有明显的变化。
在接受预负荷和血管加压药治疗的孕妇中,行择期剖宫产和椎管内麻醉时,除心率和每搏量变化外,未观察到明显的血流动力学效应。