两亲性化合物对磷脂酸代谢的影响。
The effects of amphiphilic compounds on phosphatidate metabolism.
作者信息
Brindley D N, Bowley M, Sturton R G, Pritchard P H, Cooling J, Burditt S L
出版信息
Adv Exp Med Biol. 1978;101:227-34. doi: 10.1007/978-1-4615-9071-2_22.
Amphiphilic cations interact with phosphatidate and thereby change its physical properties. This interaction can redirect phospholipid metabolism. In the presence of Mg2+ amphiphilic cations inhibit the activity of phosphatidate phosphohydrolase and stimulate that of phosphatidate cytidylyltransferase. Increasing the concentration of Mg2+ further, or adding Ca2+ have similar effects, except that Ca2+ does not stimulate phosphatidate cytidylyltransferase activity. Amphiphilic anions reverse the effects caused by the amphiphilic cations. The implication of these results are discussed in relation to the pharmacological effects of amphiphilic cationic drugs.
两亲性阳离子与磷脂酸相互作用，从而改变其物理性质。这种相互作用可以重新引导磷脂代谢。在镁离子存在的情况下，两亲性阳离子会抑制磷脂酸磷酸水解酶的活性，并刺激磷脂酸胞苷酰转移酶的活性。进一步增加镁离子的浓度，或添加钙离子也有类似的效果，只是钙离子不会刺激磷脂酸胞苷酰转移酶的活性。两亲性阴离子会逆转两亲性阳离子所引起的效应。将结合两亲性阳离子药物的药理作用来讨论这些结果的意义。
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