Department of Public Health, University of Tennessee, Knoxville, TN, USA.
Int J Public Health. 2011 Apr;56(2):231-5. doi: 10.1007/s00038-010-0183-y. Epub 2010 Sep 11.
To address the recent hypothesis that hypertension increases the risk of death from external causes.
We examined blood pressure and death from external causes among 82,037 male physicians who were screened for eligibility to enroll in the Physicians' Health Study.
During up to 6.6 years of mortality follow-up, there were 304 deaths from external causes. No association was found overall, although we observed an increased risk of non-passive external causes of death, particularly death due to falls, which was independent of various lifestyle, medical, and pharmacological risk factors.
The results of our study support this novel hypothesis. Further studies are needed to explore potential causal mechanisms between elevated BP and the risk of external death.
探讨高血压增加因外部原因导致死亡的风险这一假说。
我们对参加医师健康研究的 82037 名男性医师的血压和因外部原因导致的死亡情况进行了研究。
在长达 6.6 年的随访期间,共有 304 例因外部原因导致的死亡。虽然我们观察到非被动性外部原因死亡的风险增加,特别是因跌倒导致的死亡,但总体上并未发现这种关联,而这与各种生活方式、医疗和药物风险因素无关。
我们的研究结果支持这一假说。需要进一步的研究来探索血压升高与外部死亡风险之间的潜在因果机制。