Department of Surgery, Ankara University School of Medicine, Cigdem Mah. 28. Cad. 13/23, Gokkusagi Sitesi, Turuncu Blok, 06520, Cankaya/Ankara, Turkey.
Hernia. 2010 Dec;14(6):629-34. doi: 10.1007/s10029-010-0724-6. Epub 2010 Sep 12.
Since the first description, the use of polypropylene mesh in hernia repair has gained wide acceptance. The aim of this study was to assess whether polypropylene mesh implantation has any effects on femoral blood vessels.
A 0.5 × 1.0 cm polypropylene mesh was inserted into the rat femoral artery and vein on the right side. After 14, 28 and 90 days, the rats were reoperated. The meshes were excised for histological processing. Blood flow in the dorsum of the foot skin, femoral artery and vein were measured in all groups before mesh implantation and at 14, 28, and 90 days after mesh implantation.
Following placement of mesh graft on vascular structures, inflammation and fibrosis developed to a varying degree depending on the time elapsed. On the other hand, fibrosis did not change the histological structure of vessels. There was a decrease in both arterial and venous circulation due to the pressure of the graft.
These data suggest that fibrosis due to mesh graft can negatively affect blood flow in vessels due to mechanical pressure.
自首次描述以来，聚丙烯网片在疝修补中的应用已得到广泛认可。本研究旨在评估聚丙烯网片植入是否对股血管有任何影响。
将 0.5×1.0cm 的聚丙烯网片插入右侧大鼠股动、静脉内。术后 14、28 和 90 天再次手术，取出网片进行组织学处理。所有组在植入网片前和植入后 14、28 和 90 天测量足部皮肤背侧、股动、静脉的血流。
在血管结构上放置网片移植物后，炎症和纤维化的程度随时间的推移而不同。另一方面，纤维化并没有改变血管的组织学结构。由于移植物的压力，动脉和静脉循环都减少了。
这些数据表明，由于机械压力，移植物引起的纤维化可能会对血管中的血流产生负面影响。
